Pathological skin picking (DB) (Arbabi et al., 2008)Ĭitalopram was not statistically superior to placebo on a visual analogue scale.Ĭompulsive buying (DB) (Ninan et al., 2000a)įluvoxamine and placebo groups with comparable improvementĬompulsive buying (DB) (Black et al., 2000)Ĭompulsive buying (OL and DB) (Koran et al., 2003)Ħ3% were rated as responders in the OL. In the DB, only fluoxetine maintained improvement. Pathologic skin picking (OL and DB) (Bloch et al., 2001)ĥ3.3% were rated as responders based on the YBOCS-–PSP in the OL. Pathologic skin picking (DB) (Simeon et al., 1997)įluoxetine produced significant improvement compared to placebo Intermittent explosive disorder (DB) (Coccaro et al., 2009)įluoxetine demonstrated superiority to placebo Kleptomania (OL and DB) (Koran et al., 2007a)Įscitalopram did not significantly differ from placebo. Trichotillomania (DB) (Van Minnen et al., 2003)įluoxetine did not demonstrate statistical superiority compared to waitlist or CBT Trichotillomania (DB) (Streichenwein and Thornby, 1995)įluoxetine failed to show significant improvement compared to placebo Trichotillomania (DB) (Christenson et al., 1991)įluoxetine produced no significant improvement compared to placebo Trichotillomania (DB) (O'Sullivan et al., 1999)įluoxetine (Prozac) Clomipramine (Anafranil)įluoxetine and clomipramine produced similar positive results Trichotillomania (DB) (Ninan et al., 2000b)Ħ7% of the clomipramine group were rated as “very much improved” on the CGI compared to none assigned to placebo. Significant improvement with clomipramine compared to desipramine Trichotillomania (DB) (Swedo et al., 1989)Ĭlomipramine (Anafranil) Desipramine (Norpramin) Pathological gambling (DB) (Black et al., 2007)īupropion did not significantly differ from placebo. Sertraline did not significantly differ from placebo Pathological gambling (DB) (Sáaiz-Ruiz et al., 2005) Significant improvement for escitalopram subjects while placebo group had a relapse of gambling symptoms Pathological gambling (DB) (Grant and Potenza, 2006) Paroxetine and placebo groups with comparable improvement Pathological gambling (DB) (Grant et al., 2003) Paroxetine group significantly improved compared to placebo Pathological gambling (DB) (Kim et al., 2002) Pathological gambling (DB) (Blanco et al., 2002)įluvoxamine not statistically significant from placebo except in young males Pathological gambling (DB) (Hollander et al., 2000) The intent of this review is to provide an updated clinical picture of the previously mentioned ICDs and present evidence of potential pharmacological treatments for these disorders (see Table Table1 1). A study of 791 college students found that 82 (10.4%) met criteria for at least one lifetime ICD, demonstrating the common nature of these disorders in the general population (Odlaug and Grant, 2010). ICDs are relatively common among adolescents and adults, carry significant morbidity and mortality, and can often be effectively treated with behavioral and pharmacological therapies. The core characteristic of ICDs is difficulty resisting urges to engage in behaviors that are excessive and/or ultimately harmful to oneself or others (American Psychiatric Association, 2000). Diagnostic criteria have been proposed for pathological skin picking (PSP), compulsive sexual behavior (CSB), and compulsive buying (CB), which are currently classified under ICDs not otherwise specified (NOS). The DSM-IV formally recognizes pathological gambling (PG), kleptomania (KM), trichotillomania (TTM), intermittent explosive disorder (IED), and pyromania as impulse control disorders (ICDs).
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